VDR is a gene which encodes for a protein that acts as a receptor vitamin D, which regulates bone development and calcium absorption. A variant of the gene (rs2228570 FokI polymorphism) is associated with a lower bone mineral density in prepubescent girls of white background.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is regulated by the temporal and reciprocal pattern of on- and off occupancy of the VDRE gescheftmarketing.de/2021/07/05/erwerb-von-wissen-und-geschaeftsrichtung-durch-vdr/ by the two components, and is influenced by chromosomal positions and binding preferences for certain hormones. Microarray studies of human cells show that more than 100 genes contain VDRE. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual dataroom (VDR) is an archive of information and documents that are relevant to business, legal transactions or procedures. Access to the data, downloading, or printing is restricted. It utilizes a central computer as well as an extranet, which is a restricted-access Internet connection, to allow users to log in at specified times.
Companies involved in investment banking and in mergers and acquisitions are among the most frequent users of a VDR. They must be able to share information in a transparent manner with potential investors or buyers. The due diligence process can also require a substantial amount of data. Life science companies also utilize VDRs to store everything from clinical trial results to HIPAA documentation.